Abbreviations: C-cas3, cleaved-caspase 3; CI, confidence interval; GFAP, glial fibrillary acidic protein; (number)H, group culled hours post injury; HIE, hypoxic-ischemic encephalopathy; Iba-1, ionized calcium binding adaptor molecule 1; NeuN, neuronal nuclei. Here, CASP3 is linked to perinatal asphyxia.