To validated that ALKBH5 and IGF2BP1 are really relevant with PAQR4, correlation analyses were performed to show that ALKBH5 was negative correlated with PAQR4 and IGF2BP1 was positive correlated with that of PAQR4 in the HCC samples (Fig. 3G–I). The gene discussed is IGF2BP1; the disease is hepatocellular carcinoma.