We utilized a cohort of 441 autopsy-confirmed AD cases from the Mayo Clinic Brain Bank with genome-wide genotypes and temporal cortex (TCX) biochemical measures of AD-related protein endophenotypes including APOE, Aβ40, Aβ42, total tau, and p-Tau from soluble (TBS), membrane (TX), and insoluble (FA) tissue fractions. Here, APOE is linked to Alzheimer disease.