As expected, the APOE-ε4 variant (rs429358) and the proximal NECTIN2 variant (rs283815) significantly associated with AD risk, Thal phase, Braak stage, amyloid PET, CSF amyloid and p-Tau, plasma p-Tau and as reported previously for APOE-ε4, also CAA [32]. Here, NECTIN2 is linked to Alzheimer disease.