Specifically, higher amyloid PET, CSF pTau, plasma pTau, lower CSF and plasma Aβ have congruent associations with the AD risk variant at the APOE locus and other variants that behave like APOE with respect to brain biochemistry associations (i.e. SLC9A9, STRN4 variants). The gene discussed is SLC9A9; the disease is Alzheimer disease.