Importantly, this study identified additional, biologically congruent associations for five of the seven novel loci including SLC9A9, SCIN, NPAS3, ITGB4, and STRN4. Based on the associations of the APOE locus, we would expect increased Aβ40TX (SLC9A9 and STRN4) to correlate with increased AD risk while increases in APOETX (SCIN and NPAS3) and Aβ40TBS (ITGB4) would correlate with decreased AD risk. The gene discussed is NPAS3; the disease is Alzheimer disease.