Importantly, they also implicate at least two of the novel variants more broadly in AD risk and neuropathology (variants near SLC9A9 and SCIN), and four with additional AD-related endophenotypes (near SLC9A9, NPAS3, ITGB4, and STRN4) in a direction that is consistent with the brain biochemical findings and known associations with the well-established APOE risk variant. This evidence concerns the gene NPAS3 and Alzheimer disease.