Alterations to lipid metabolism in the ALS-Glia subtype are evidenced by APOBR, APOC1, and APOC2 overexpression compared to ALS-Ox and ALS-TD patients (Fig. 6, Fig. S9), and may further reflect the elevated APOE and LPL expression seen in disease-associated microglia18,50. The gene discussed is APOE; the disease is amyotrophic lateral sclerosis.