Elevated expression of nonsense-mediated decay transcripts CHKB-CPT1B and SLX1B-SULT1A4 in ALS-TD patients may implicate a TDP-43 associated mechanism similar to those detailed in the process of cryptic exon splicing in STMN2 and UNC13A100–103. The gene discussed is SLX1B; the disease is thanatophoric dysplasia.