COX4I2 and early-onset autosomal dominant Alzheimer disease: Briefly considering common disease themes between Alzheimer’s disease and the ALS-Ox subtype, expression of oxidation-associated transcripts COX4I2, NDUFA4L2, and OXR1 is consistent with reported literature68–70, although CP is known to be upregulated in Alzheimer’s55 (Fig. 6).