Evidence for alterations to the extracellular matrix, in the frontal and motor cortex of ALS-Ox patients, is observed in the downregulated expression of ADAMTSL4, ADAMTS7, ADAMTS14, COL1A1, COL1A2, COL2A1, COL3A1, COL4A6, COL6A3, COL8A1, COL14A1, COL18A1, and TAGLN (Fig. 6, Fig. S10; Supplementary Data 10). The gene discussed is COL2A1; the disease is amyotrophic lateral sclerosis.