CP and amyotrophic lateral sclerosis: The ALS-Ox subtype is defined by oxidative stress, evidenced by upregulated expression of OXR1 and SOD1 and downregulation of CP (ceruloplasmin), UCP2, and oxidative phosphorylation genes NDUFA4L2, TCIRG1, and COX4I253–58 (Fig. 6, Fig. S10).