Interestingly, we observe upregulated transcription of GABRA1, GAD2, HTR2A, and PCSK1 in ALS-Ox patients, which have been previously reported to be downregulated in Alzheimer’s patients71, suggesting distinct synaptic signaling pathological mechanisms (Figs. 3a, 6). This evidence concerns the gene PCSK1 and amyotrophic lateral sclerosis.