The ALS-Ox subtype is defined by oxidative stress, evidenced by upregulated expression of OXR1 and SOD1 and downregulation of CP (ceruloplasmin), UCP2, and oxidative phosphorylation genes NDUFA4L2, TCIRG1, and COX4I253–58 (Fig. 6, Fig. S10). Here, SOD1 is linked to amyotrophic lateral sclerosis.