In the context of AAV8-Tbg-Cre infection followed by DEN+CCl4, all tumors that appeared to be HCC were uniformly positive for YFP, indicating that they were derived from hepatocytes, although they were also positive for progenitor cell markers, Sox9, Cd133, Cd44 and delta-like 1 homolog. The gene discussed is SOX9; the disease is hepatocellular carcinoma.