Furthermore, IDHR172K and KrasG12D double-mutant murine livers showed a greatly accelerated tumorigenic potential compared to KrasG12D-only mutant livers, with metastatic tumors expressing iCCA histopathology and expression of a biliary marker, CK19, but lacking expression of an HCC marker, HepPar1. The gene discussed is KRT19; the disease is hepatocellular carcinoma.