TP53 and hepatocellular carcinoma: Furthermore, Tschaharganeh et al. [51] provided compelling evidence that transduction of differentiated hepatocytes with Yap, a potent liver oncogene with increased activity in both HCC and iCCA [52], together with knockdown of trp53 tumor suppressor, lead to dedifferentiation of hepatocytes and acquisition of stem and progenitor cell characteristics.