Furthermore, on the flip side, it was shown that p53 re-expression in embryonic carcinoma cells deficient in p53 or HL-60 promyelocytic leukemia cells was shown to trigger their differentiation [105, 106] and may partly explain the association between the presence of p53 mutations and stem cell characteristics in certain cancers [107, 108]. Here, TP53 is linked to embryonal carcinoma.