As for the analysis of promoter methylation, it was found that SOCS1 (P-value = 0.45 and Z-score = -0.78) and SOCS3 methylation (P-value = 0.89 and Z-score = -0.156) were not significantly different between the individuals with obesity and normal-weight (Fig. 3). Here, SOCS1 is linked to obesity disorder.