As for the analysis of promoter methylation, it was found that SOCS1 (P-value = 0.45 and Z-score = -0.78) and SOCS3 methylation (P-value = 0.89 and Z-score = -0.156) were not significantly different between the individuals with obesity and normal-weight (Fig. 3). The gene discussed is SOCS1; the disease is obesity due to melanocortin 4 receptor deficiency.