GJA1 and amyotrophic lateral sclerosis: In a pathophysiological context, we also evaluated the activation of the PI3K/AKT pathway using astrocytes from the hSOD1G93A transgenic ALS mouse model, where the increased levels of Cx43 in astrocytes represent an inherent trait [1], and the correlation between astrocyte reactivity and neurodegenerative processes is well documented [7].