In vivo heterograft tumor monitoring for 24 days, it was found that overexpression of PHF5A significantly promoted the tumor formation of GC cells, which was manifested by increased tumor size (P < 0.05; Fig. 5E, F), weight (P < 0.01; Fig. 5G) and KI67 expression (Fig. 5H). Here, MKI67 is linked to gastric cancer.