We found five TAD blocks with CoMut genes/events specific to ATC with certain mutation frequency in The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) cohort, including CoMut pairs MAST/NSUN4, AM129B/TRUB2, COL5A1/PPP1R26, PPP1R26/GPSM1/CCDC183, and PRAC2/DLX4 (Fig. 2C, F). The gene discussed is TRUB2; the disease is thyroid cancer.