CX3CR1 and myeloid sarcoma: Moreover, demyelinated Cx3cr1 KO mice and/or mice that express a human MS-associated CX3CR1 variant display poor remyelination, impaired microglial phagocytosis, and decreased OPC migration and proliferation (Cardona et al., 2018; Huang et al., 2006; Lampron et al., 2015; Mendiola et al., 2022).