Similarly, miR-141-3p downregulation showed to participate in PCa metastasis and invasiveness via activating NF-κB signaling [109]., it showed to enrich the stemness characteristics of prostate cancer stem cells (PCSCs) by targeting a cohort of pro-metastasis genes including CD44, Enhancer of zest homolog 2 (EZH2), and Ras homologous (Rho) GTPases [110]. The gene discussed is EZH2; the disease is Familial prostate cancer.