The most considerable pathways have been found which are Proteoglycans in cancer (hsa05205), Notch Signaling (hsa04330), PPAR signalling pathway (hsa03320), Pathways in cancer (hsa05200), Diseases of signal transduction (R-HSA-5663202), CD28 dependent PI3K/Akt signalling (R-HSA-389357), ABC transporters in lipid homeostasis (R-HSA-1369062), VEGFA-VEGFR2 Signaling Pathway (hsa04370), and Thyroid hormone signalling pathway (hsa04919). The gene discussed is PIK3CA; the disease is cancer.