Molecular docking and ADMET properties against VEGFA (PDB ID: 1FLT) and PIK3R1 (PDB ID: 5M6U) showed sesamin, galangin, and coumestrol were the top three compounds that might play a role on therapeutic target in the treatment of infertility and infertility mediated cancer progression. The gene discussed is PIK3R1; the disease is cancer.