Then we selected VEGFA and PIK3R1 proteins for the docking approach based on the Maximal Clique Centrality (MCC) value of the cytohubba plugin and literature analysis indicates that VEGFA and PIK3R1 most common genes responsible for the progression of several cancer, including Endometrial cancer [62, 63], Ovarian cancer [23, 64], Cervical cancer [24, 65] and Thyroid cancer [66, 67]. Here, PIK3R1 is linked to thyroid gland carcinoma.