TP53 and adenoma: Furthermore, the incidence of primary lung tumors, such as adenoma and adenocarcinoma, which has not been reported in previous papers [17, 27], was 65.4, 62.5, and 45.4% in the 25, 50, and 75 mg/kg groups of FVB-Trp53+/- mice, respectively, supporting the reports that FVB/N mice are susceptible to lung tumorigenesis [28, 29].