INS and obesity due to melanocortin 4 receptor deficiency: Both rs79837492 and rs2968545 were associated with a decrease in mean %VAT; rs79837492 was significantly associated with CPR, SHBG, and triglycerides, and rs2968545 was significantly associated with glucose, HOMA-IR, insulin, and triglycerides at P = 0.05 in MEC-APS without adjustment for total adiposity, but neither variant was significantly associated with the obesity-related biomarkers after total adiposity adjustment.