To sum up, “Jiaotai Pill” combined with head massage therapy consistent with 5-tone rhythm has exact clinical efficacy, which can significantly improve the PSQI, ISI, HAMA and TCM symptom scores of insomnia patients, effectively reduce the expression of serum IL-6 and IL-8 factors, and then improve the discomfort symptoms of patients. This evidence concerns the gene CXCL8 and insomnia measurement.