TNF and insomnia: At the same time, some studies have shown that Jiaotai Pill can act on the circadian rhythm control center and sleep-wake center of the body through related pathways.[26] Modern pharmacological studies have found that the rat model of water extract of Jiaotai Pill was induced by intragastric administration of chlorophenylalanine, and the concentrations of tumor necrosis factor-α, IL-6, IL-1β and other cytokines in serum and brain tissue of insomnia rats were detected, and the contents of sleep-related neurotransmitters were detected.