We can further investigate the role of intracellular signaling pathways and gene co-expression, regarding the elucidation of the role of TGF-β1 signaling in specific pathogenic environments as an important direction for future research; this may pave the way for the development of strategies to modulate these disease processes to develop the most effective therapy plan better for CRC patients.[52]. This evidence concerns the gene TGFB1 and colorectal carcinoma.