When the stimulus is limited, 2 roles for Gal-8 on T cells, rGal-8, ameliorate EAE.[41] In another study, it was demonstrated that rGal-8 therapy reduced the severity of experimental autoimmune uveitis pathology by anti-inflammatory effects.[42] In 1 study, Gal-8 knocked out mice with severe EAE, demonstrating Gal-8’s anti-inflammatory effects.[41]. The gene discussed is LGALS8; the disease is autoimmune uveitis.