LGALS1 and osteoarthritis: It is expressed in various organs and tissues like synovia, tumors, and osteoarthritis.[20–27] Endothelial cells, which come from lymphatic and vascular vessels, are a great source of secreted Gal-8 in tissues to deliver lectin activity via the surrounding microenvironment and circulating cells.[25,28–31] Some studies show that Gal-8 and other members of this family, like galectin-1, have similar effects on T and B cell responses.[32,33] For example, Galectin-4 is involved in bacterial killing.[34]