Furthermore, some studies have revealed impaired glymphatic transport of CSF tracers in spontaneously hypertensive rats compared to normotensive rats, suggesting that hypertension could impair glymphatic function at an early age.[32,37] In addition, one study showed that EPVS decreased the expression of polarized AQP4, and impaired glymphatic transport coexisted in spontaneously hypertensive rats,[32] showing that decreased AQP4 polarization and EPVS may be related to impaired glymphatic function in SHRs. This evidence concerns the gene AQP4 and hypertensive disorder.