On the other hand, HIF-2α has a higher impact on the genes involved in iron metabolism and the EPO gene, but both HIF-1α and HIF-2α regulate VEGF and GLUT-1.[9] VEGFA, an endothelial mitogen, is the most notable of these HIF-1/2 targets because it is considered to be the primary controller of tumor angiogenesis. This evidence concerns the gene EPAS1 and neoplasm.