Despite recent developments in survival rates, targeted therapy, and patient outcomes for HNSCC have not significantly increased in recent years, which, when combined with the disease’s increasing occurrence, increases the need for more potent treatment options.[1,2,4]Hypoxia or scarcity of chemical elements may be markers of solid tumors, and they adapt by activating HIF-1, a transcription problem that triggers the expression of quasi-links in nursing angiogenic molecules in an anoxic atmosphere. The gene discussed is HIF1A; the disease is head and neck squamous cell carcinoma.