Being a universal biomarker of a disease feature common to multiple neurodegenerative pathologies, plasma NfL levels are higher not only in AD but also in several other neurodegenerative diseases including amylotrophic lateral sclerosis, frontotemporal lobal degeneration and primary tauopathies such as progressive supranuclear palsy and corticobasal syndrome [10▪▪,11]. Here, NEFL is linked to Alzheimer disease.