NOTCH1 and autosomal dominant polycystic kidney disease: Some of these DMGs were reported in an earlier study associated with ADPKD (Woo et al. 2014), for example, PKD1 (a major driving gene in ADPKD), NOTCH1 (which regulates the cell differentiation pathway), and SLC22A18 (participating in cellular transport) were all hypermethylated in the gene body.