SLC2A1 and Hirschsprung disease: Our analysis shows that a GLUT1‐ and p75‐expressing perineurium appears as a discrete boundary around the ENS neurons of hybrid structures and is detectable in the submucosal plexus at more cranial levels closer to the normoganglionic zone than in the myenteric plexus where they are restricted to more caudal regions closer to the aganglionic gut in HSCR patients.