In various AD models, crocin has caused significant alleviation of disease progression and improvement by different mechanisms including blocking Aβ-initiated apoptosis [164], preventing mitochondrial damage [165], attenuating expression of TNF-α and IL-1β mRNA [166], reducing Aβ deposition in the brain hippocampus, and reducing ROS generation via its anti-inflammatory effects [166, 167]. The gene discussed is TNF; the disease is Alzheimer disease.