Also, rutin alone (25 and 50 mg/kg), and rutin along with selenium has shown significant anti-HD effects in a 3-NP-induced rat and mice model of HD evinced by restoration of biochemical, behavioral, and histological alterations which were further caused due to inhibiting astrocyte activation, increasing BDNF, and improving cholinergic and monoaminergic transmission [158, 159]. This evidence concerns the gene BDNF and Huntington disease.