Once tumor cells metastasize to and colonized in the lymph node, tumor-secreted cytokines, such as vascular endothelial growth factors C (VEGFC) and VEGFD, induce proliferation and growth of new lymphatic vessels (lymphangiogenesis) by binding to VEGF receptors on lymphatic endothelial cells, which further promotes the tumor cells metastasizing to distant lymph nodes in the next echelon in an orderly sequence through lymphaticovenous connections to the general systemic circulation (Nathanson 2003). Here, VEGFD is linked to neoplasm.