High glucose-induced activation of the nuclear factor (NF)-κB pathway in vascularcells is also a key contributor to the pathogenesis of diabeticcomplications.4,32–34 Here, we observe that in diabetes the expression of Tnfrsf21(TNF receptor superfamily member 21) in BMVs is significantly decreased by diabetes(Table 2). The gene discussed is TNFRSF21; the disease is diabetes mellitus.