TSC22D3 and diabetes mellitus: Tnfrsf21activates the NF-κB pathway and triggers cell apoptosis.35 In addition, we furtherobserve that in diabetes, expression of neuron-derived orphan receptor 1 (Nr4a3) andTSC22 domain family protein 3 (Tsc22d3) in BMVs is significantly increased (Table 2) while it is notchanged in RMVs.