Among the 43 genes of RMVs that were changed under diabetic conditions, the DAVIDfunctional annotation analysis identifies three enriched KEGG pathways: (i) theaminoacyl-tRNA biosynthesis pathway, including Iars, Yars, Nars, Gars and Mars;(ii) the focal adhesion pathway, including Igf1r, Pdgfra, Bcl2 and Parvb; and(iii) the prostate cancer pathway including Igf1r, Pdgfra and Bcl2 (Table 3). This evidence concerns the gene IGF1R and Familial prostate cancer.