Wen et al. (55) found that stimulating human umbilical vein endothelial cells with circRNA-0006896-rich exosomes isolated from the sera of patients with unstable angina/vulnerable plaque atherosclerosis increased miRNA-1264 and DNMT1 protein expression, activated the JNK/STAT3 signaling pathway, and promoted vascular endothelial cell proliferation and migration. Here, MAPK8 is linked to angina unstable.