It is worth mentioning that this study mainly focuses on the downstream pathway of miR-140-3p (ADAM10/Notch), and the upstream signal pathway of miR-140-3p is also worth studying, and there have been some research reported: Wei et al., 2022 reported that Circ_0020123 enhances the cisplatin resistance in NSCLC cells by sponging miR-140-3p/HOXB5 76; Wang et al., 2022 revealed that Hypoxia-induced PVT1 promotes lung cancer chemoresistance by PVT1/miR-140-3p/ATG5 axis 77. This evidence concerns the gene HOXB5 and lung cancer.