AKT3 and esophageal squamous cell carcinoma: Besides, Yao et al. found that circHIPK3 facilitated AKT serine/threonine kinase 3 (AKT3) expression by sponging miR-124, thus forming the circHIPK3/miR-124/AKT3 axis to promote ESCC cell proliferation, migration, and epithelial-mesenchymal transition 72.