C-Myb is a critical oncogenic transcription factor, which was reported to be involved in the upstream regulator of circHIPK3 in CRC, the results of a ChIP assay implied that c-Myb can bind to the promoter region of circHIPK3, and the overexpression of c-Myb significantly enhanced the promoter activity and expression of circHIPK3, therefore these results support that circHIPK3 was a direct target of c-Myb in CRC 45. Here, MYB is linked to colorectal carcinoma.