According to Silva et al., intensive training for self-titrating insulin doses combined with structured SMBG can significantly reduce the HbA1c level, but with no significant difference from less intensive training (p=0.051).19 In our study, the existence of IHD as co-morbidity in the LAI group (14.8%) compared with that in the SAI group (4.8%) yielded a larger mean HbA1c level reduction in the SAI group. This evidence concerns the gene INS and myocardial ischemia.