FUS and amyotrophic lateral sclerosis: On the other hand, the C-terminal mutants of FUS, such as FUSH517D, FUSR521C, and FUSP525L, which harbor various mutations in FUS identified as ALS-linked mutations, show evident recruitment to SGs under stress conditions (Higelin et al., 2016; Ichiyanagi et al., 2016; Supplementary Figure 6A).