FUS and amyotrophic lateral sclerosis: In addition, FUS, TIA-1, hnRNPA2B1, and hnRNPA1, which are also nuclear RBPs, are closely related to pathological protein aggregation in ALS and FTD (Neumann et al., 2009; Kim et al., 2013; Ling et al., 2013; Mackenzie et al., 2017; Wolozin and Ivanov, 2019).