IL4 and allergic disease: This study indicated that type 2 helper T cell (Th2) response with IL-4–producing MCT type (high tryptase/PAR-2, low chymase/Ang II) significantly dominates in EPP cattle than in fascioliasis cattle (Figure 3), that is, suggesting that EPP cattle will be triggered by type I hypersensitivity (allergic disease) (10).