F2RL1 and fascioliasis: In this context, the numbers per 1 mm2 of periendothelium fibroblasts expressing PAR-2 but not angiotensin II (Ang II) increased significantly in EPP cattle (626.1 ± 56.3, n = 10, P = 0.0000101, one-way ANOVA, two-tailed test) compared with that in fascioliasis cattle (1.7 ± 0.7, n = 6) (Figures 3A, B).