VA deficiency has been reported to increase the risk of Treg-to-Type 17 helper T cell (Th17) reprogramming, resulting in the induction of enteritis (26) and IgE-mediated food allergy (27); that is, it was suggested to enhance allergic responses via Th17 because Treg with the immunosuppressive function is reduced by VA deficiency. The gene discussed is IGHE; the disease is food allergy.