Among multiple dysregulated factors, Notch signaling activation also causes elevation of the urokinase-type plasminogen activator (uPA), β1-integrin, β-catenin, matrix metalloproteinase (MMP)-2, and MMP-9 levels, conferring the cancer cells with even greater ability to invade new tissues (Shimizu et al., 2011; Lai et al., 2018; Wagley et al., 2020). This evidence concerns the gene PLAU and cancer.