SOX2 and cancer: Zhan et al. [100] found that the sex-determining region Y-box2 (SOX2) overlapping transcript (SOX2OT) was highly expressed in bladder cancer and that increased SOX2OT expression promoted self-renewal, migration, invasion, and tumorigenicity of bladder cancer stem cells via “sponging” of miR-200c and subsequent enhancement of the expression of SOX2, a vital regulator of cancer stemness [101,102].