Moreover, the oncogenic lncRNA HOXA cluster antisense RNA 2 (HOXA-AS2) was found to promote the stemness of bladder cancer cells by elevating the expression levels of the cancer stem cell markers ALDH1A1, CD44, HMGA2, KLF4, and OCT4 by regulating the miR-125b/smad2 axis [103]. This evidence concerns the gene POU5F1 and cancer.