TLX1 and cancer: Wang et al. [60] showed that high expression of BCAR4 is associated with advanced stage and metastasis of bladder cancer and that BCAR4 significantly promotes cell proliferation, migration, and invasion of bladder cancer by directly binding to miR-644a and upregulating the expression of T cell leukemia homeobox 1 (TLX1), an important transcription factor involved in the progression of many cancers [61,62].