In this study, by combining tracing results and c-FOS immunofluorescence staining in VGLUT1:tdTomato mice, we demonstrated the putative Vme-Vpdm-VPM pathway and the potential VpdmVGLUT1-VPM pathway underlying comorbid anxiety, implying neural connections between proprioception and emotions. Here, SLC17A7 is linked to Anxiety.