Among them, compared with AD genes through GeneCards2 and MalaCards3 databases, we found that CAP2, VSNL1, PAK1, SYP, ENC1, NEFM, ADCYAP1, SVOP, CHGB are related to Alzheimer’s disease; LOC387856 (CCDC184) and SYP are associated with dementia. The gene discussed is NEFM; the disease is early-onset autosomal dominant Alzheimer disease.