In some brain tumor (Mukherjee et al., 2016; Tan et al., 2018), and hydrocephalus (Tourdias et al., 2009) models, AQP4 has been proved to be correlated with single ADC values or multi-parameter ADC values, but such a rule cannot be verified in our experimental model. The gene discussed is AQP4; the disease is Hydrocephalus.