PIK3R1 and acute myeloid leukemia: Since PIK3R1 is a known inhibitor of PI3K/Akt pathway, and PI3K/Akt pathway have role to adjust drug resistance and glycolysis, we consider the inhibition of PI3K/Akt pathway by PI3KR1 is the reason that miR-155 knockout MV411 cells impaired glycolysis and thus overcome the treatment resistance in FLT3-ITD+AML (Figure 8).