EGFR and lung carcinoma: It showed that both engineered BaF3 cells harboring EGFRL858R/T790M/C797S or EGFR19del/T790M/C797S were sensitive to HCD3514, as well as the PC-9-OR cells (EGFR19del/T790M/C797S expressing PC-9 lung cancer cells), with enhanced inhibition the phosphorylation of EGFR.