The antitumor potency of HCD3514 in BaF3-EGFR19del/T790M/C797S mouse xenograft model was further confirmed by Western blotting that showed decreased phosphorylation of EGFR and the downstream signaling phosphorylation of Erk level, indicating that the tumor growth inhibition of the resistant triple mutant model due to the inhibition of the activation of EGFR and EGFR-related molecule. Here, EGFR is linked to neoplasm.