CDK1 (OS: P = 0.00091 PFS: P = 1.7E-05), CDK5 (OS: P = 0.0093 PFS: P = 0.043), CDC20 (OS: P = 0.0076 PFS: P = 7.8E-05), CCNA2 (OS: P = 0.0069 PFS: P = 1.4E-07), CCNB1 (OS: P = 0.00064 PFS: P = 2.4E-07) and CCNB2 (OS: P = 0.0015 PFS: P = 0.00013) were up-regulated in HCC patients under poor OS and PFS with alcohol consumption. This evidence concerns the gene CCNB1 and hepatocellular carcinoma.