Our study aimed to comprehensively explored cell cycle-related genes (cyclin dependent kinase 1: CDK1, cyclin dependent kinase 5: CDK5, Cell-division cycle protein 20 homologue: CDC20, Cyclin A2: CCNA2, Cyclin B1: CCNB1, and Cyclin B2: CCNB2) expression levels and correlation with prognosis features of HCC patients based on the online databases. This evidence concerns the gene CDC20 and hepatocellular carcinoma.