Only 13 genes (CDC45, CDK1, CHEK1, ESPL1, MCM2, MCM4, MCM6, ORC1, ORC6, PKMYT1, PLK1 and PLK4) among the DNs had obvious perturbation effects on 197 non-small cell lung cancer cell lines (Supplementary Table S4). The gene discussed is CDC45; the disease is non-small cell lung carcinoma.