We observed that the expression level of S100A11 in pan-cancer was closely related to many immune response pathways, including P53 pathway, glycolysis, apoptosis, inflammatory response, IL2/STAT5 signaling, hypoxia, and IL6/JAK/STAT3 signaling, suggesting that patients with the elevated expression of S100A11 might be rich in immune cell infiltration. The gene discussed is TP53; the disease is cancer.