In this study, we observed that S100A11 was significantly highly expressed in 24 of 33 tumors, including ACC, BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, OV, PAAD, PCPG, READ, SKCM, STAD, TGCT, THCA, UCEC, and UCS; however, it was significantly lowly expressed in DLBC, KICH, and LAML. This evidence concerns the gene S100A11 and adrenal cortex carcinoma.