HLA-C and cancer: Additionally, we also observed that S100A11 high expression was significantly related to MHC (major histocompatibility complex) genes (Figure 8A), immunosuppressive genes (Figure 8B), chemokines (Figure 8C), chemokine receptors (Figure 8D), and immune checkpoints (Sup-Figure 6) in pan-cancer, suggesting that patients with increased S100A11 expression might have an immunosuppressive TME.