Circ-0000105 indirectly upregulated the expression of PIK3R1 by absorbing miR-498, and the increase in circ-0000105 inhibited apoptosis and deteriorated proliferation of LC cells, which was related to the high T stage of LC patients and poor differentiation of the tumor 15. Here, PIK3R1 is linked to laryngotracheoesophageal cleft.