However, there is a lack of prognosis data related to patients with HNC under treatment with chemotherapy drugs and CD38 expression; meanwhile, we found it very interesting that patients with higher expression of CD38 suggest a lower prognosis, for example ovarian cancer patients were treated with chemotherapy drugs that specific affect cells in the G1/S phase (Figure S1), as our previous experimental results suggested 29. This evidence concerns the gene CD38 and ovarian cancer.