Notably, four ferroptosis-related pathways, including proteasome (NES = 1.6748, adjusted p-value = 0.0263, 5q-value = 0.0181), cysteine and methionine metabolism (NES = 1.7277, adjusted p-value = 0.0195, q-value = 0.0134), p53 signaling pathway (NES = 1.5643, adjusted p-value = 0.0263, q-value = 0.0181) and DNA replication (NES = 1.9783, adjusted p-value = 0.0195, q-value = 0.0134), were found to be significantly enriched in high-risk MM patients (Supplementary Figure 9). The gene discussed is TP53; the disease is Miyoshi myopathy.