For instance, by catalyzing H3K79 succinylation at the promoter region of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) to promote its expression, KAT2A reinforces the migration and invasion of many transformed cells such as human pancreatic ductal adenocarcinoma cells (62), liver cancer cells (63), and glioblastoma cells (21). The gene discussed is YWHAZ; the disease is pancreatic ductal adenocarcinoma.