FH and cancer: Mutations of genes encoding enzymes participating in mitochondrial metabolism such as SDH, fumarate hydratase (FH), IDH1/2 can activate the NFE2-related factor 2 (NRF2) pathway towards enhanced anti-oxidative ability and reduced ferroptosis of cancer cells by increasing succinate, fumarate, or R(-)-2-hydroxyglutarate levels that inhibit various α-ketoglutarate-dependent dioxygenases (78).