MMP2 and cancer: For example, FBN1 over-expression is associated with advanced gastric malignancies that can promote cancer progression by activating TGF-β1 and PI3K/Akt signaling; succinylation of FBN1 at K672 is widely distributed in gastric tumors that blocks its interactions with matrix metallopeptidase 2 (MMP2) and thus prevents it from MMP2-mediated local degradation and collagen remodeling (54).