PGAM1 and neoplasm: In general, chromatin succinylation is correlated with an active transcriptional program and promotive on aerobic glycolysis and cell proliferation, and the associations between succinylation and tumorigenesis have already been established in many studies (52) such as the tumor-promotive role of phosphoglycerate mutase 1 (PGAM1) K99 succinylation in liver cancers (53) and that of fibrillin 1 (FBN1) K672 succinylation in gastric cancers (54).