ERBB2 and neoplasm: The following eight non-therapeutic risk factors proven to independently predict either LRR, DM, DFS, or OS in multivariate analysis were used to define risk groups: age (≤40 years vs.>40 years), tumor location (inner quadrant vs. other quadrants), pT stage (T2 vs. T1), number of positive nodes (two to three vs. one), LVI (yes vs. no), histological grade (grade 3 vs. grades 1–2), hormonal receptor (negative vs. positive), and HER2 status (positive vs. negative).