Positive specific cellular response was displayed in 13 out of 36 (36.1%) after the first dose of the mRNA-1273 vaccine in our cancer patients, with median (IQR) IFN-γ levels of 62.25 (8-554.3) mUI/ml; while in 33 out of 36 (91.7%) after the second dose, with median (IQR) IFN-γ levels of 1,915 (690.8-1970) mUI/ml, significantly higher than baseline (p<0.001). Here, IFNG is linked to cancer.