From monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and newly diagnosed MM to relapsed and refractory multiple myeloma, the rate of +1q increases, which implies a relationship between +1q and disease progression (11), which might be due to the derangement of genes located on 1q21, including MCL-1, IL-6R, and CKS1B, all of which are closely related to myeloma prognosis (11, 12). The gene discussed is IL6R; the disease is monoclonal gammopathy.