In this study, a prognostic model of 9 genes (CASP3, CASP4, CASP8, CASP9, GSDMC, IL18, IL6, PLCG1, and PRKACA) was constructed based on bioinformatics analysis with the survival data of LGG patients in the TCGA and CGGA cohorts and validated it by both clinical prognosis and correlation with tumor immunity. The gene discussed is CASP8; the disease is neoplasm.