On the other hand, treatment of lymphocytes or FDC–lymphocyte cocultures with LPS or ICs resulted in inconsistent regulation of PC differentiation- and MM-associated genes (BCL2, XBP1, CCND1, 2, and 3, MYC, SDC1, BMI1, IRF4, PRDM1, FGFR3, and NSD2). Here, XBP1 is linked to Miyoshi myopathy.